Methodist Episcopal Church, South (also known as the Old Daphne Methodist Church) is a historic church at 1608 Old County Road in Daphne, Alabama. It was built in 1858 in a Greek Revival style. The building was added to the National Register of Historic Places in 1980.

The building was constructed on land originally owned by Mr. and Mrs. William Howard since 1833. Another building may have stood on the site at an earlier date, since the associated graveyard contains markers dating back to 1847. The church and graveyard was purchased by the Methodist Episcopal Church from the Howards for $5 (equivalent to about $110 today) in 1869. The church changed hands once over the years, and the belfry was damaged on two different occasions, 1906 and 1916, by storms. The church was severely damaged by Hurricane Frederic in 1979, and has since been handed over to a local preservation group.

The Grand Bay Savanna- Little River Road Tract Addition was acquired with financial support from the U.S. Fish and Wildlife Service in 2004, through the National Coastal Wetlands program. This tract serves as an addition to the Grand Bay Savanna Addition Tract State Nature Preserve acquired in 1996. The addition consists of 113 acres of piney flatwoods south of Grand Bay, Alabama.